PLLACELL vs PLLA Fillers: What’s the Difference and Why It Matters
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As the demand for collagen-stimulating treatments continues to grow, so does the range of products available to practitioners. Two popular categories often confused are PLLACELL and PLLA-based fillers like Ecolla and aesPLLA.
While all these products contain poly-L-lactic acid (PLLA) — a powerful biostimulant — they are fundamentally different in purpose, formulation, and application.
Let’s break it down so you can choose the right product for your treatment goals.
What Are PLLA Fillers?
Products like aesPLLA and Ecolla fall into the category of PLLA-based dermal fillers. These are used to:
Restore volume in areas of facial fat loss
Stimulate collagen production in deeper layers of the skin
Lift and contour over time for long-lasting rejuvenation
Typical Use Areas:
-Midface
-Temples
-Jawline
-Nasolabial folds
Key Ingredients:
-PLLA microparticles – stimulate long-term collagen production
-Carboxymethylcellulose (CMC) – suspends the particles for smoother injection
These products are injected deep into the dermis or subcutaneous layers using cannulas, and results develop gradually over several weeks. They are best suited for clients seeking structural rejuvenation and volume replacement.
What Is PLLACELL?
PLLACELL, exclusively distributed by HUK Aesthetics, is not a filler. It is an advanced skin booster designed to:
-Improve skin texture, tone, and hydration
-Stimulate collagen and elastin without volumising
-Revitalise the skin for a smoother, brighter appearance
Key Ingredients:
-PLLA (35 mg) – boosts collagen and skin elasticity
-Polynucleotides (8 mg) – supports tissue repair and regeneration
-Vitamin C & Glutathione – antioxidants for skin brightening and protection
-Sodium Hyaluronate – hydrates and plumps the skin
This formulation is delivered superficially into the epidermis or upper dermis and should not be injected with cannulas or into deep tissue.
How PLLACELL Is Applied:
To ensure optimal results and avoid complications, PLLACELL is administered via:
-Mesotherapy technique (microinjections into superficial dermis)
-Microneedling
-BAP technique (5-point superficial application)
-MTS dermarolling
This makes it ideal for clients seeking skin rejuvenation without volume — particularly for dull, dehydrated, or aging skin.
Key Differences at a Glance:
| Feature | PLLA Fillers (aesPLLA, Ecolla) | PLLACELL |
|---|---|---|
| Product Type | Filler (Collagen Biostimulator) | Skin Booster |
| Main Goal | Volume restoration | Skin revitalisation |
| Application Depth | Deep dermis / subcutis | Epidermis / upper dermis |
| Delivery Method | Cannula or deep needle injection | Meso, microneedling, BAP, dermaroller |
| Ingredients | PLLA + CMC | PLLA + PN + Vitamin C + Glutathione + HA |
| Results | Volume, lift, structural support | Glow, elasticity, improved texture |
Why This Matters for Practitioners
Understanding the difference between a skin booster and a volumising filler is crucial not just for treatment success — but for patient safety.
Using a deep-injection filler like aesPLLA incorrectly in a superficial plane can lead to lumps, nodules, or uneven results. Likewise, using a product like PLLACELL in deep tissue with a cannula will not only be ineffective, but also off-label and unsafe.
Knowing your products — and their purpose — ensures you deliver safe, targeted, and effective treatments every time.