Polynucleotides vs. Skin Boosters: What’s the Difference?
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In the world of aesthetics, skin health is no longer just about hydration — it’s about regeneration, prevention, and long-term skin quality. With so many products promising a “glow-up,” two standout treatments continue to gain momentum in clinics across the UK: skin boosters and polynucleotides.
But what’s the difference between the two — and how do you know which is right for your clients? Let’s break it down.
What Are Skin Boosters?
Skin boosters are injectable treatments designed to deeply hydrate and revitalise the skin. Usually made with non-crosslinked hyaluronic acid (HA), they improve moisture levels, enhance skin texture, and give the skin a radiant, plump appearance.
Benefits of Skin Boosters:
-Hydrates from within
-Improves skin elasticity and tone
-Reduces fine lines
-Gives a dewy, glowing finish
-Ideal for younger clients or as a “pre-event” refresh
Skin boosters are perfect for clients looking for a natural glow with minimal downtime. Treatments like Profhilo, Seventy Hyal, and Lumi-Pro are widely loved for their visible, yet subtle results.
What Are Polynucleotides?
Polynucleotides are a new generation of regenerative injectables derived from purified DNA fragments (often salmon or trout sourced). Rather than simply hydrating, they work at a cellular level to stimulate fibroblasts, promote tissue repair, and support long-term skin health.
Benefits of Polynucleotides:
-Encourages cell regeneration and tissue repair
-Reduces inflammation and oxidative stress
-Improves elasticity, firmness, and skin quality
-Supports skin affected by scarring, pigmentation, or ageing
-Suitable for under-eye rejuvenation and acne-prone skin
Popular products like Plinest, Newest, and Vitaran offer targeted treatment options for clients needing more than just hydration — they’re for those ready to invest in deeper skin restoration.
Which One Should You Use?
The good news? You don’t always have to choose.
Skin boosters are ideal for hydration and quick wins.
Polynucleotides are the go-to for long-term regeneration and more complex skin concerns.
Many practitioners combine the two in treatment plans — starting with polynucleotides to lay the groundwork for skin healing, followed by skin boosters to enhance glow and hydration.