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Nucleofill 20 (Nucleofill Medium Replacement)

Nucleofill 20 (Nucleofill Medium Replacement)

£51.99
£51.99
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Nucleofill 20 (formerly Nucleofill Medium) is a bio-stimulating injectable treatment enriched with polynucleotides, designed to reduce the visible signs of aging. It promotes skin regeneration and repairs cellular damage, leaving the skin looking more youthful and radiant.

Professional Use Only

Additional Information

Nucleofill 20 (formerly known as Nucleofill Medium) is a powerful skin treatment enriched with polynucleotides (PN), which provide anti-aging, anti-inflammatory, and antioxidant benefits.

These polynucleotides stimulate fibroblast activity, promoting collagen and elastin production, enhancing tissue regeneration, and improving skin elasticity and overall quality. Nucleofill 20 is suitable for all skin types and can be applied to the face, neck, hands, or abdomen.

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Nucleofill 20: Advanced Cellular Renewal from Within

Nucleofill 20 is a next-generation polynucleotide injectable designed to revitalise the skin at a cellular level. Formulated with a 2% polynucleotide gel, this bio-stimulating treatment activates fibroblasts to boost collagen and elastin production, enhancing skin elasticity and firmness. By deeply hydrating and regenerating tissue, Nucleofill 20 helps reduce the appearance of fine lines, wrinkles, and uneven skin tone, delivering a visibly smoother and more youthful complexion.

Targeted Skin Rejuvenation for Lasting Radiance

With its powerful antioxidant and anti-inflammatory properties, Nucleofill 20 supports skin repair while protecting against oxidative stress. Suitable for all skin types and areas - including the face, neck, hands, and abdomen - it offers a versatile solution for clients seeking subtle, natural-looking improvement. Previously known as Nucleofill Medium, this CE-marked injectable integrates seamlessly into any advanced aesthetic protocol, making it ideal for those looking to restore skin vitality with minimal downtime.

The Power of Nucleofill 20

  • Regeneration, Hydration and Lift

    Nucleofill 20 is a cutting-edge bio-stimulating injectable designed to improve overall skin quality through deep regeneration and hydration. Powered by polynucleotides (PN), it works beneath the surface to stimulate cellular renewal, activate fibroblast cells, and boost collagen and elastin production. The result is noticeably fresher, firmer, and more radiant skin, achieved without over-volumising or altering facial contours - ideal for clients seeking natural-looking rejuvenation.

  • Cellular Repair and Antioxidant Protection

    Formulated with a 2% concentration of PN, Nucleofill 20 supports the skin’s ability to repair damage, calm inflammation, and defend against oxidative stress. Its anti-inflammatory and antioxidant properties make it highly effective for treating early signs of ageing, dullness, and environmentally stressed skin. This injectable not only improves texture and tone but also strengthens the skin’s structural integrity - delivering results that are both immediate and progressive.

  • Versatile Rejuvenation for Multiple Areas

    Unlike many treatments limited to the face, Nucleofill 20 is suitable for use on the neck, hands, abdomen, and other commonly neglected areas that show signs of ageing. Its lightweight gel formulation penetrates deeply to hydrate, firm, and revitalise, making it a versatile choice for full-spectrum skin renewal. Whether addressing fine lines, pigmentation, or mild laxity, Nucleofill 20 offers a comprehensive solution with minimal downtime and lasting aesthetic benefits.

The Benefits of Nucleofill 20

Deep Hydration:
Restores moisture at a cellular level, leaving skin plump, smooth, and radiant.

Stimulates Collagen and Elastin:
Activates fibroblasts to strengthen the skin’s structure and improve elasticity.

Reduces Fine Lines and Wrinkles:
Softens early signs of ageing for a more youthful, refreshed appearance.

Improves Skin Tone and Texture:
Enhances clarity and smoothness by supporting healthy cell turnover.

Anti-Inflammatory and Antioxidant Protection:
Helps calm irritation and defends against environmental stressors.

Fades Pigmentation and Scarring:
Supports the reduction of post-inflammatory marks and uneven tone.

Tightens and Firms:
Offers a subtle lifting effect, particularly useful for sagging or lax skin.

Versatile Treatment Areas:
Suitable for face, neck, décolletage, hands, and abdomen.

Low Risk, Minimal Downtime:
Non-volumising, with minimal side effects and a short recovery period.

Natural-Looking Results:
Delivers progressive improvements without altering facial structure.

Shop the Nucleofill Range

  • Nucleofill 20

    Nucleofill 20 (formerly Nucleofill Medium) is a bio-stimulating injectable treatment enriched with polynucleotides, designed to reduce the visible signs of aging. It promotes skin regeneration and repairs cellular damage, leaving the skin looking more youthful and radiant.

    SHOP HERE

  • Nucleofill 25

    Nucleofill 25 (formerly Nucleofill Strong) is an advanced injectable polynucleotide (PN) treatment designed to rejuvenate the skin and reduce the visible signs of aging. This powerful bio-stimulator works by promoting cellular regeneration, replenishing hydration to dull skin, and gradually releasing collagen for long-lasting, natural results.

    SHOP HERE

  • Nucleofill Hair

    Nucleofill Hair (formerly Nucleofill Medium Plus) is an advanced polynucleotide injectable designed to promote hair growth and combat hair loss. This treatment works by stimulating hair follicles and enhancing blood circulation, helping restore hair to its natural strength, health, and thickness.

    SHOP HERE

  • Nucleofill Eye

    Nucleofill Soft Plus is specifically designed to treat the delicate eye area, offering a rejuvenating solution for this sensitive part of the face. This dermal filler effectively addresses small wrinkles and dark circles under the eyes, leaving the skin looking smoother and more radiant.

    SHOP HERE

Nucleofill 20 FAQs

What is Nucleofill 20?

Nucleofill 20 is a polynucleotide-based injectable treatment designed to stimulate skin regeneration, boost hydration, and improve elasticity. It is ideal for clients seeking natural, progressive anti-ageing results without added volume.

What areas can be treated with Nucleofill 20?

Nucleofill 20 is suitable for use on the face, neck, décolletage, hands, and abdomen - anywhere experiencing signs of dehydration, ageing, or skin laxity.

How does it work?

It contains 2% polynucleotides that activate fibroblast cells, stimulating collagen and elastin production while supporting skin repair and hydration. The formula also has antioxidant and anti-inflammatory properties, protecting the skin from oxidative stress.

Who is it suitable for?

Nucleofill 20 is safe for all skin types and is ideal for clients aged 25 and over who are concerned about early signs of ageing, dullness, or skin laxity. It is not recommended during pregnancy, breastfeeding, or for individuals with a fish allergy.

How many sessions are required?

Typically, a course of 2–4 treatments spaced 2 to 4 weeks apart is recommended. Maintenance sessions can be performed every 6–9 months depending on individual needs.

Is there any downtime?

Downtime is minimal. Some clients may experience slight redness, swelling, or bruising at the injection sites, which usually subsides within 24–48 hours.

What’s the difference between Nucleofill 20 and Nucleofill 25?

The main difference is in concentration: Nucleofill 20 contains 2% polynucleotides, while Nucleofill 25 (also known as Nucleofill Strong) contains 2.5%, making it more suitable for treating deeper lines or more advanced skin laxity.

Can it be combined with other treatments?

Yes, Nucleofill 20 can complement treatments such as microneedling, chemical peels, or laser resurfacing. It’s often included in comprehensive skin rejuvenation protocols.

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At HUK Aesthetics, we're committed to providing only the highest quality aesthetic injectables, ensuring every product we supply is 100% authentic, and, where required, CE certified. This guarantees our products meet or exceed the rigorous UK and European standards for safety, efficacy, and performance, giving our clients confidence in the treatments they provide.